A PDZ Switch for a Cellular Stress Response
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چکیده
منابع مشابه
A PDZ Switch for a Cellular Stress Response
The accumulation of misfolded porins in the periplasm of bacteria triggers a proteolytic cascade, initiated by activation of DegS, a member of the family of HtrA proteases. Activation of DegS ultimately leads to the expression of genes encoding the periplasmic protein folding machinery. A new study now reveals that binding of exposed C-termini of unassembled porins to the PDZ domain of DegS ind...
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10 Abstract The PSD-95/Dlg-A/ZO-1 (PDZ) domain is highly expanded and diversified in 11 metazoan where it is known to assemble diverse signalling components by virtue of interactions 12 with other proteins in sequence-specific manner. In contrast, in bacteria it monitors protein 13 quality control during stress response. The distribution, functions and origin of PDZ domain14 containing proteins...
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ژورنال
عنوان ژورنال: Cell
سال: 2004
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(04)00453-2